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Lapatinib ditosylate powder cas 388082-78-8 is the ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity.
Product introduction：
CAS: 388082-78-8
MF: C41H40ClFN4O11S3
Molecular Weight: 925.5 g/mol
Applications: Antimalarial drug, anti-cancer drug
Description: Lapatinib ditosylate powder cas 388082-78-8 is the ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity.
Application: Lapatinib ditosylate powder cas 388082-78-8 reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.
Certificate of analysis
|
Test items |
Standards |
Results |
|
Appearance |
Yellow powder |
Conforms |
|
Identification |
IR |
Conforms |
|
Melting point |
242-249℃ |
245.5-247.6℃ |
|
Total impurities |
≤1.0％ |
0.6% |
|
Loss on drying |
≤1.0％ |
0.2％ |
|
Heavy metals |
≤20ppm |
Conforms |
|
Assay |
≥99.0% |
99.4% |
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